Choroidal thickness changes in the acute attack period in patients with familial mediterranean fever.

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Ophthalmologica. 2016;235(2):72-7. doi: 10.1159/000442216. Epub 2015 Dec 5.

Choroidal Thickness Changes in the Acute Attack Period in Patients with Familial Mediterranean Fever.

Gundogan FC1, Akay F, Uzun S, Ozge G, Toyran S, Genç H.

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Abstract

PURPOSE:

The aim of this study was to evaluate choroidal thickness changes during acute attacks of familial Mediterranean fever (FMF).

METHODS:

Fifty patients with FMF and 50 healthy controls were included. Choroidal thickness of each participant was measured at the foveola and horizontal nasal and temporal quadrants at 500-µm intervals to 1,500 µm from the foveola using spectral-domain optical coherence tomography. White blood cell count, erythrocyte sedimentation rate (ESR) and serum levels of fibrinogen and C-reactive protein (CRP) were evaluated. The clinical findings (peritonitis, arthritis and pleuritis) were noted.

RESULTS:

Choroidal thickness was significantly thicker at all measurement points in FMF patients compared to healthy controls during an acute attack (p < 0.05). There were positive correlations between the choroidal thickness and ESR, fibrinogen and, particularly, CRP levels. Clinical findings did not change the choroidal thickness significantly (p > 0.05).

CONCLUSIONS:

Increased choroidal thickness in the acute phase of FMF is possibly related to the inflammatory edematous changes in the choroid.

© 2015 S. Karger AG, Basel.

Comment in

Temperature Control Function of the Choroid May Be the Reason for the Increase in Choroidal Thickness during the Acute Phase of Familial Mediterranean Fever. [Ophthalmologica. 2016]

Reply to the Letter by Kaya et al. Entitled “Temperature Control Function of the Choroid May Be the Reason for the Increase in Choroidal Thickness During the Acute Phase of Familial Mediterranean Fever”. [Ophthalmologica. 2016]

Response to the Letter by Kosker et al. Entitled ‘Choroidal Changes in Patients with Familial Mediterranean Fever’. [Ophthalmologica. 2016]

Choroidal Changes in Patients with Familial Mediterranean Fever. [Ophthalmologica. 2016]

PMID:

26637112

DOI:

10.1159/000442216

[Indexed for MEDLINE]